Sunday, August 17, 2014

Essential Fatty Acids ( EFA) A miracle Supplements

History:

       Around year 1908, Researchers noted that heart disease was unknown among Greenland natives, even though these people subsisted almost entirely on meat. The same lack of heart disease was found when studied again in the 1930s.
        The native Greenlander diet consists of almost nothing but the meat and blubber from seals and small whales. Because these mammals feed exclusively on cold-water fish, their flesh is very high in omega-3 fatty acids, which in turn confer their protection on the humans who eat them. Native Greenlanders who move to Denmark begin eating a typical European diet quickly develop levels of heart disease comparable to their Danish neighbors.

Essential Fatty Acids:

                 Not all fats are bad. In fact an essential fat is just that – essential to the body. The body cannot manufacture these essential fats and therefore must get them from food. There two important essential fatty acids are Omega -3 fatty acids and Omega-6 fatty acids.
  Our body uses omega oils to regulate a wide variety of cellular functions and substances, including the level of prostaglandins, active hormone like substances that regulate almost every bodily function, including the work of the heart and kidneys, the constriction of blood vessels, healing and repair, immune function, allergy defense, digestion, inflammation, menstrual cramps, body temperature, and pressure in the eyes, ears, and joints.
There are three important classes of prostaglandins: each is made from different fatty acids and is influenced almost entirely by our diet.
The first class, class 1, quench inflammation, and are derived from a fatty acid called dihomogammalinolenic acid (DGLA). This is found in only one substance known to man: mother’s milk. However, our body can make its own DGLA from GLA, a healthy omega -6 fatty acid. In turn our bodies can make GLA from linoleic acid, which is found in nuts and seeds.
Class 3 prostaglandins are anti-inflammatory agents. They are exclusively from omega-3 fatty acids, which primarily from fish oils.
Class 2 prostaglandins are powerfully proinflammatory fire starters. Our bodies make them from meat or vegetable oils that contain omega- 6 fatty acids. Many of these omega-6s are an important linchpin in the inflammatory avalanche.
Our body needs all three classes of prostaglandins, but it needs them in a proper balance. The imbalance in the consumption of these essential fatty acids is the main reason for the imbalance in our body’s production of these hormones.
 The generally accepted optimal ratio of dietary intake of Omega 6 fatty acids and Omega 3 fatty acids is 4:1. This means we should take in four times as much of Omega 6 as we do Omega 3. But Omega- 6 fatty acids are abundant in our diet but Omega- 3 fatty acids are very rare in our diet.
On average we consume a ratio of 20:1 or even 40:1 of these fatty acids in our diet. This results in our bodies producing significantly more inflammatory products than anti-inflammatory products. Our bodies simply too inflamed.  Too many class 2 prostaglandins – fueled by an unhealthy diet – may be an important factor in many 
chronic inflammatory illnesses.

Omega – 3 fatty Acids:

Two important forms of omega –3 fatty acids come in fatty fish like Solomon and mackerel. They are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)

Why are omega-3s and -6 so important?

 Simply because many of the chemical signals that stimulate a cell to act do so by metabolizing and changing the fatty layers of cell membrane. The signals that can impact layer range from adrenaline to histamine as well as powerful neurotransmitters such as serotonin and dopamine. If the fatty layer is deficient or impaired, chemical signals don’t have proper effect, and the body’s functions are impaired.

On September 8, 2004, the U.S. Food and Drug Administration gave "qualified health claim" status to EPA and DHA omega-3 fatty acids, stating, “Supportive but not conclusive research shows that consumption of EPA and DHA [omega-3] fatty acids may reduce the risk of coronary heart disease.”

The Canadian government has recognized the importance of DHA omega-3 and permits the following biological role claim for DHA: "DHA, an omega-3 fatty acid, supports the normal development of the brain, eyes and nerves.

Alarming Facts:

1. Largest-ever study of deaths shows heart ailments have replaced communicable diseases as the biggest killer in rural & urban India.
Heart diseases have emerged as the number one killer in both urban and rural areas of the country. Source   Mail Today  |   New Delhi, April 12, 2010 |

About 25 per cent of deaths in the age group of 25- 69 years occur because of heart

diseases.
 In urban areas, 32.8 per cent deaths occur because of heart ailments,

 while this percentage in rural areas is 22.9 percent



 
2.
 7 lakh Indians died of cancer last year: WHO


Nearly seven lakh Indians die of cancer every year, while over 10 lakh are newly diagnosed with some form of the disease. 

According to the latest World Cancer Report from the World Health Organisation (WHO), more women in India are being newly diagnosed with cancer annually. As against 4.77 lakh men, 5.37 lakh women were diagnosed with cancer in India in 2012. 

In terms of cancer deaths, the mortality rate among men and women in India is almost the same. While 3.56 lakh men died of cancer in 2012 in India, the corresponding number for women was 3.26 lakh. 
3. Arthritis is now the No.1 problem both in India and in the western world. About 14% of the Indian population suffers from some form of arthritis. This effectively means that close to 150 million people are victims of arthritis in India. 
Source : 16 March 2011 - 9:49am IST | Place: Bangalore | Agency: DNA, http://www.dnaindia.com/bangalore/report-new-treatment-will-cure-arthritis-in-three-weeks-1520531

4.Asthama :


In India, rough estimates indicate a prevalence of between 10% and 15% in 5-11 year old children.

(Asthma attacks all age groups but often starts in childhood. It is a disease characterized by recurrent attacks of breathlessness and wheezing, which vary in severity and frequency from person to person. In an individual, they may occur from hour to hour and day to day.
This condition is due to inflammation of the air passages in the lungs and affects the sensitivity of the nerve endings in the airways so they become easily irritated. In an attack, the lining of the passages swell causing the airways to narrow and reducing the flow of air in and out of the lungs.
Causes
Asthma cannot be cured, but could be controlled. The strongest risk factors for developing asthma are exposure, especially in infancy, to indoor allergens (such as domestic mites in bedding, carpets and stuffed furniture, cats and cockroaches) and a family history of asthma or allergy. A study in the South Atlantic Island of Tristan da Cunha, where one in three of the 300 inhabitants has asthma, found children with asthmatic parents were much more likely to develop the condition.)



5. Auto Immune problems 

It has been estimated that autoimmune diseases are among the ten leading

causes of death among women in all age groups up to 65 years.



In both autoimmune and inflammatory diseases, the condition arises through aberrant reactions of the human adaptive or innate immune systems. In autoimmunity, the patient’s immune system is activated against the body's own proteins. In chronic inflammatory diseases, neutrophils and other leukocytes are constitutively recruited by cytokines and chemokines, leading to tissue damage.
Mitigation of inflammation by activation of anti-inflammatory genes and the suppression of inflammatory genes in immune cells is a promising therapeutic approach

 Uses of Omega – 3 Fatty Acids




Omega-3 fatty acids for cardiovascular health and disease

Omega-3 fatty acids for asthma

Omega-3 fatty acids for other diseases
Type II diabetes and metabolic syndrome
Inflammatory bowel disease (Crohn's disease and ulcerative colitis)
Rheumatoid arthritis
Renal disease
Systemic lupus erythematosus
Bone density/osteoporosis

Omega-3 fatty acids and cognitive function, dementia, and neurological diseases

Omega-3 fatty acids for organ transplantation

Omega-3 Fatty Acids, Effects on Eye Health

Several studies suggest omega-3 fatty acids may help protect adult eyes from macular degeneration and dry eye syndrome. Essential fatty acids also may help proper drainage of intraocular fluid from the eye, decreasing the risk of high eye pressure and glaucoma


How They Help Your Health

·         Blood fat (triglycerides).Fish oil supplements can lower elevated triglyceride levels. Having high levels of this blood fat puts you at risk for heart disease. DHA alone has also been shown to lower triglycerides.
·         Rheumatoid arthritis. Fish oil supplements (EPA+DHA) can curb stiffness and joint pain. Omega-3 supplements also seem to boost the effectiveness of anti-inflammatory drugs.
·         Depression. Some researchers have found that cultures that eat foods with high levels of omega-3s have lower levels of depression. Fish oil also seems to boost the effects of antidepressants and may help the depressive symptoms of bipolar disorder.
·         Baby development. DHA appears to be important for visual and neurological development in infants.
·         Asthma. A diet high in omega-3s lowers inflammation, a key component in asthma. But more studies are needed to show if fish oil supplements improve lung function or cut the amount of medication a person needs to control the condition.
·         ADHD. Some studies show that fish oil can reduce the symptoms of ADHD in some children and improve their mental skills, like thinking, remembering, and learning. But more research is needed in this area, and omega-3 supplements should not be used as a primary treatment.
·         Alzheimer's disease and dementia. Some research suggests that omega-3s may help protect against Alzheimer's disease and dementia, and have a positive effect on gradual memory loss linked to aging. But that's not certain yet.



84 Health Benefits of Omega-3 Fatty Acids




1.     There is strong evidence that omega-3 fatty acids have a beneficial effect in bipolar disorder.
2.     Omega-3 fatty acid supplementation is associated with reduced mania and depression in juvenile bipolar disorder.
3.     Clinical studies have reported that oral fish oil supplementation has beneficial effects in rheumatoid arthritis and among some asthmatics.
4.     Fish oil improves tubular dysfunction, lipid profiles and oxidative stress in patients with IgA nephropathy.
5.     Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients.
6.     Omega 3 fatty acids improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity.
7.     Omega-3 in modest doses reduces cardiac deaths, and in high doses reduces nonfatal cardiovascular events.
8.     Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with myocardial infarction.
9.     Omega-3 fatty acid reduce the total mortality and sudden death in patients with left ventricular systolic dysfunction.
10.        Raising blood levels of omega-3 fatty acid levels may be 8 times effective than distributing automated external defibrillators (AEDs), and 2 times more effective than implanting implanting cardioverter defibrillators (ICDs) in preventing sudden death.
11.        Omega-3 fatty acid supplementation reduces total mortality and sudden death in patients who have already had a heart attack.
12.        Consuming small quantities of fish is associated with a reduction in coronary heart disease.
13.        Omega-3 fatty acids and vitamin D supplementation results in a substantial reduction incoronary calcium scores and slowed plaque growth.
14.        Omega-3 fatty acids prevent atrial fibrillation after coronary artery bypass surgery.
15.        Omega-3 fatty acid supplementation has a therapeutic effect in children with ADHD.
16.        A combination of omega-3 and omega-6 fatty acids as well as magnesium and zinc consumption provide a beneficial effect on attentional, behavioural, and emotional problems of children and adolescents.
17.        Fish oil supplementation has a significant therapeutic effect on children with autism.
18.        Omega-3 fatty acids appear to be an effective treatment for children with autism.
19.        The consumption of omega-3 fatty acid supplements decreases homocysteine levels indiabetic patients.
20.        Omega-3 fatty acids improve macro- and microvascular function in subjects with type 2 diabetes mellitus.
21.        In patients with stable coronary artery disease, an independent and inverse association exists between n-3 fatty acid levels and inflammatory biomarkers.
22.        Omega-3 fatty acids improve endothelial function in peripheral arterial disease.
23.        Fish oil has a beneficial effect on blood viscosity in peripheral vascular disease.
24.        Fish oil supplementation improves walking distance in peripheral arterial disease.
25.        The omega-3 fatty acid decosapentaenoic acid (DPA) reduces the risk of peripheral arterialdiseaseassociated with smoking.
26.        An 8-month treatment with omega-3 fatty acids (EPA and DHA) has a positive effects, such asdecreasing inflammation, in patients with cystic fibrosis.
27.        Omega-3 fatty acids may have a protective effect against mucus over-production caused by pulmonary bacterial colonization in cystic fibrosis.
28.        Omega-3 fatty acid supplementation reduces inflammatory biomarkers, erythrocyte sedimentation rate, and interleukin-8 concentrations in cystic fibrosis patients.
29.        DHA increases resistance to Pseudomonas aeruginosa infection.
30.        EPA supplementation has therapeutic value in the treatment of chronic hepatitis C patients.
31.        EPA and DHA have therapeutic value in the treatment of systemic lupus erythmeatosus.
32.        Omega-3 fish oil reduces the severity of symptoms in patients with systemic lupus erythematosus.
33.        Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortalityin diabetic women.
34.        Higher plasma concentrations of EPA and DPA are associated with a lower risk of nonfatalmyocardial infarction among women.
35.        Omega-3 fatty acid consumption is inversely associated with incidence of hypertension.
36.        Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.
37.        The consumption of fish reduces the risk of ischemic stroke in elderly individuals.
38.        A moderate intake of EPA and DHA may postpone cognitive decline in elderly men.
39.        Omega-3 fatty acids may have a therapeutic effect on postpartum depression.
40.        Omega-3 fatty acids may have therapeutic value in the treatment of dry eye syndrome.
41.        Omega-3 fatty acid supplementation exhibits therapeutic value in the treatment of children with attention-deficit/hyperactivity disorder (ADHD) symptomatology.
42.        Fish consumption reduces the risk of ischemic stroke in men.
43.        Omega-3 Fatty acids supplementation prevents and reverses insulin resistance.
44.        Omega-3 fatty acids prevent the formation of urinary calcium oxalate stone formation.
45.        Omega-3 fatty acids are beneficial for children with bronchial asthma.
46.        Omega 3 fatty acid supplementation may contribute to the prevention of early preterm birth in both low-risk and high-risk pregnancies.
47.        Fish consumption is associated with a 63% reduction in prostate cancer-specific mortality.
48.        Omega 3 fatty acids decrease the severity of autoimmune disorders.
49.        Eicosapentaenoic acid (EPA) may have a therapeutic role in attenuating pulmonary hypertension.
50.        Omega-3 fatty acids resulted in an improvement in weight bearing in dogs with osteoarthritis.
51.        Primary open-angle glaucoma patients have reduced blood levels of DHA and EPA.
52.        Omega-3 fatty acids alleviate insulin resistance and fatty liver in obese mice.
53.        Intake of eicosapentaenoic and docosahexaenoic acids from fish may be associated with areduced prevalence of allergic rhinitis.
54.        Cod liver oil (omega-3 Fatty Acids) reduces the need for NSAIDs in patients withrheumatoid arthritis.
55.        Omega-3 Fatty Acids has significant therapeutic benefits and drug sparing activity in the treatment of rheumatoid arthritis.
56.        Diets containing EPA and DHA have an inhibitory effect on breast cancer growth and metastasis.
57.        Dietary Omega-3 fatty acids may protect smokers against chronic obstructive pulmonary disease (COPD).
58.        Omega-3 fatty acids were shown to be more effective than placebo for depression in both adults and children in small controlled studies and in an open study of bipolar depression.
59.        The omega-3 fatty acid EPA is as effective as fluoxetine (Prozac) in treating major depressive disorder.
60.        A diet low in trans-unsaturated fat and rich in omega-3 fatty acids and olive oil may reducethe risk of age-related macular degeneration.
61.        Higher intake of omega 3 fatty acids may reduce the risk of pneumonia.
62.                        Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients.
63.                        Omega 3 fatty acids improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity.
64.                        Omega-3 in modest doses reduces cardiac deaths, and in high doses reduces nonfatal cardiovascular events.
65.                        Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with myocardial infarction.
66.                        Omega-3 fatty acid reduce the total mortality and sudden death in patients with left ventricular systolic dysfunction.
67.                        Raising blood levels of omega-3 fatty acid levels may be 8 times effective than distributing automated external defibrillators (AEDs), and 2 times more effective than implanting implanting cardioverter defibrillators (ICDs) in preventing sudden death
68.                        Omega-3 fatty acid supplementation reduces total mortality and sudden death in patients who have already had a heart attack.
69.                        Consuming small quantities of fish is associated with a reduction in coronary heart disease.
70.                        Omega-3 fatty acids and vitamin D supplementation results in a substantial reduction incoronary calcium scores and slowed plaque growth.
71.                        Omega-3 fatty acids improve macro- and microvascular function in subjects with type 2 diabetes mellitus.
73.                        In patients with stable coronary artery disease, an independent and inverse association exists between n-3 fatty acid levels and inflammatory biomarkers.
74.                        Omega-3 fatty acids improve endothelial function in peripheral arterial disease.
75.                        Fish oil has a beneficial effect on blood viscosity in peripheral vascular disease.
76.                        Fish oil supplementation improves walking distance in peripheral arterial disease.
77.                        The omega-3 fatty acid docosapentaenoic acid (DPA)reduces the risk of peripheral arterial disease associated with smoking.
78.                        Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortality in diabetic women.
79.                        Higher plasma concentrations of EPA and DPA are associated with a lower risk of nonfatalmyocardial infarction among women.
80.                        Omega-3 fatty acid consumption is inversely associated with incidence of hypertension.
81.                        Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.
82.                        The consumption of fish reduces the risk of ischemic stroke in elderly individuals.
83.                        Fish consumption reduces the risk of ischemic strokin men.
84.                        Eicosapentaenoic acid (EPA) may have a therapeutic role in attenuating pulmonary hypertension. 

Omega-3 Fatty Acids, Effects on Child & Maternal Health


Safety aspects of omega-3 fatty acids



How much omega-3 fatty acids should you take?
There are no standard doses for omega-3 fatty acids. The American Heart Association (AHA) recommends 1 gram per day of EPA+DHA for people with heart disease. Higher doses -- between 2 to 4 grams per day -- are used to lower triglycerides. If you need to take omega-3 fatty acid supplements, ask your health care provider what dosage you should use.
Can you get omega-3 fatty acids naturally from foods?
Good food sources of omega-3 fatty acids include:
Coldwater fish, like mackerel, tuna, salmon, and sardines

Flaxseed and canola oils
Soybeans and tofu
Walnuts
DOSAGE


Special conditions ---- After food

Arthritis
 One capsule 3 times a day
Inflammatory bowel disease
One capsule 3 times a day
Heart disease, Eye problem
One capsule 3 times a day
Diabetes , Blood Pressure
One capsule 3 times a day
Asthma
One capsule 3 times a day
Skin conditions
One capsule 3 times a day
Auto Immune Disorders
One capsule 3 times a day
Reynaud’s Disease
One capsule 3 times a day

Regular Supplementation:                        One capsule after food


Reference Books 

1. Readers Digest – Foods That Harm Foods That Heals
2. Secrets of supplements
3. Dr.Atkins’ Age Defying Diet
4. What Your Doctor Doesn't Know About Nutritional Medicine May Be
Killing You – Ray D.Strand, M.D
5. Optimal Health Revolution- Duke Johnson,MD
6. The Vitamin Prescription for Life – Dr.Richard N. Firshein



  
Source : www.amway.in

  
NUTRILITE ®
Salmon Omega - 3
utilizes naturally extracted oil from
Salmon, Anchovy, Mackerel &
Sardines to introduce fatty acids
into your system.
Improving your Omega 3 to
Omega 6 ratio is an optimal way
to balance the lipids in your
body—which, in turn, supports a
healthy heart.
KEY PRODUCT MESSAGE
GOOD FOR HEART, BEST FOR HEALTH
FEATURES AND BENEFITS
A good omega balance is great for your heart.
 This product supports overall heart health by providing a balanced ratio of
omega-3 fatty acids (DHA and EPA).
 Researchers believe that improving the ratio of omega-3 to omega-6 fatty acid
intake may add benefits to good health.
 Contains Omega 3 sourced from a variety of fishes. The primary being
Salmon.
POTENTIAL CONSUMERS

 Individuals interested in supporting healthy heart function.
How to use
 Take 1 softgel daily with water. To be taken with meals.
Adopt these best practices while using NUTRILITE Salmon Omega
Children under 12 years of age, pregnant women or nursing mothers, or anyone
with a medical condition should consult with a physician before using this product.
 Keep out of reach of children.